(182) Schultz J, Uddin Z, Singh G, Howlader MMR. Glutamate sensing in biofluids: recent advances and research challenges of electrochemical sensors. Analyst. 2019 Nov 22. doi: 10.1039/c9an01609k. [Epub ahead of print] Review. PubMed PMID: 31755483. https://www.ncbi.nlm.nih.gov/pubmed/31755483

(181) Fazzari J, Singh G. Effect of glutaminase inhibition on cancer-induced bone pain. Breast Cancer (Dove Med Press). 2019 Sep 11;11:273-282. doi: 10.2147/BCTT.S215655. eCollection 2019. https://www.ncbi.nlm.nih.gov/pubmed/31571981

(180) Miladinovic T, Singh G. Spinal microglia contribute to cancer-induced pain through system xC --mediated glutamate release. 2019 May 29;4(3):e738. doi: 10.1097/PR9.0000000000000738. eCollection 2019 May-Jun. https://www.ncbi.nlm.nih.gov/pubmed/31583353

(179) Miladinovic T, Sharma, M. Phan A, Geres H, Ungard R, Linher-Melville K, Singh G. Activation of hippocampal microglia in a murine model of cancer-induced pain. J Pain Res 2019 Mar 18; 12: 1003-1016. https://www.ncbi.nlm.nih.gov/pubmed/30936739

(178) Linher-Melville K, Sharma M, Nakhla P, Kum E, Ungard R, Park J, Rosa D, Gunning P, Singh G. Inhibiting STAT3 in a murine model of human breast cancer induced bone pain delays the onset of nociception.  Mol Pain 2019 Vol 15: 1744806918823477. https://www.ncbi.nlm.nih.gov/pubmed/30799695

(177) Ungard RG, Linher-Melville K, Nashed M, Sharma M, Wen J, Singh G. xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain. Mol Pain 2019 Jan-Dec; 15:1744806918822185. https://www.ncbi.nlm.nih.gov/pubmed/30799686


(176) Zhu YF, Kwiecien JM, Dabrowski W, Ungard R, Zhu KL, Huizinga JD, Henry JL, Singh G. Cancer pain and neuropathic pain are associated with A β sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord. Mol Pain. 2018 Jan-Dec; 14:1744806918810099.  https://www.ncbi.nlm.nih.gov/pubmed/30324862

(175) Young K, Singh G. Biological Mechanisms of Cancer-Induced Depression. Front Psychiatry. 2018 Jul 10;9:299. doi: 10.3389/fpsyt.2018.00299. eCollection 2018. https://www.ncbi.nlm.nih.gov/pubmed/30042700

(174) Miladinovic T, Ungard RG, Linher-Melville K, Popovic S, Singh G. Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain. Mol Pain. 2018 Jan-Dec;14:1744806918776467. https://www.ncbi.nlm.nih.gov/pubmed/29761734

(173) Linher-Melville K, Singh G. The complex roles of STAT3 and STAT5 in maintaining redox balance: Lessons from STAT-mediated xCT expression in cancer cells. Mol Cell Endocrinol 2017 Aug 15; 451:40-52. https://www.ncbi.nlm.nih.gov/pubmed/28202313

(172) Zhu YF, Ungard R, Zacal N, Huizinga JD, Henry JL, Singh G. Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo. Pain Rep. 2017 Jun 22;2(4):e603. doi: 10.1097/PR9.0000000000000603. eCollection 2017 Jul. https://www.ncbi.nlm.nih.gov/pubmed/29392218

(171) Fazzari J, Balenko MD, Zacal N, Singh G. Identification of capsazepine as a novel inhibitor of system xc- and cancer-induced bone pain. J Pain Res 2017 Apr 18; 10:915-925. https://www.ncbi.nlm.nih.gov/pubmed/28458574


(170) Nashed MG, Ungard RG, Young K, Zacal NJ, Seidlitz EP, Fazzari J, Frey BN, Singh G. Behavioural effects of using sulfasalazine to inhibit glutamate released by cancer cells: a novel target for cancer-induced depression. Sci Rep 2017 Jan 25; 7:41382. https://www.ncbi.nlm.nih.gov/pubmed/28120908


(169) Fazzari J, Linher-Melville K, Singh G. Tumour-derived glutamate: linking aberrant cancer cell metabolism to peripheral sensory pain pathways. Curr Neuropharmacol 2017; 15(4):620-636. https://www.ncbi.nlm.nih.gov/pubmed/27157265


(168) Linher-Melville K, Nashed MG, Ungard RG, Haftchenary S, Rosa DA, Gunning PT, Singh G. Chronic inhibition of STAT3/STAT5 in treatment-resistant human breast cancer cell subtypes: convergence on the ROS/SUMO pathway and its effects on xCT expression and system xc- activity. PLoS One 2016 Aug 11; 11(8):e0161202.



(167) Zhu YF, Ungard R, Seidlitz E, Zacal N, Huizinga J, Henry JL, Singh G. Differences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain. Mol Pain 2016 Mar 1; 12. https://www.ncbi.nlm.nih.gov/pubmed/27030711


(166) Miladinovic T, Nashed MG, Singh G. Overview of glutamatergic dysregulation in central pathologies. Biomolecules 2015 Nov 11; 5(4):3112-3141.



(165) Nashed MG, Seidlitz EP, Frey BN, Singh G. Depressive-like behaviours and decreased dendritic branching in the medial prefrontal cortex of mice with tumours: a novel validated model of cancer-induced depression. Behav Brain Res 2015 Nov 1; 294:25-35. https://www.ncbi.nlm.nih.gov/pubmed/26222786


(164) Linher-Melville K, Haftchenary S, Gunning P, Singh G. Signal transducer and activator of transcription 3 and 5 regulate system xc- and redox balance in human breast cancer cells. Mol Cell Biochem 2015 Jul; 405(1-2):205-221. https://www.ncbi.nlm.nih.gov/pubmed/25896132


(163) Habib E, Linher-Melville K, Lin HX, Singh G. Expression of xCT and activity of system x are regulated by NRF2 in human breast cancer cells in response to oxidative stress. Redox Biol 2015 Mar 18; 5:33-42. https://www.ncbi.nlm.nih.gov/pubmed/25827424


(162) Fazzari J, Lin H, Murphy C, Ungard R, Singh G. Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain. Sci Rep 2015; 5:8380. https://www.ncbi.nlm.nih.gov/pubmed/25670024


(161)  Linher-Melville K, Singh G. The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells. BMC Cancer 2014; 14: 415. https://www.ncbi.nlm.nih.gov/pubmed/24913037


(160)  Zhu X, Amir E, Singh G, Clemons M, Addison C. Bone-targeted therapy for metastatic breast cancer - Where do we go from here? A commentary from the BONUS 8 meeting. Journal of Bone Oncology 2014; 3: 1-4. https://www.ncbi.nlm.nih.gov/pubmed/26909291


(159) Ungard RG, Seidlitz EP, Singh G. Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain 2014; 155: 28-36. https://www.ncbi.nlm.nih.gov/pubmed/23999057


(158) Singh G. Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel) 2014; 7: 192-206. https://www.ncbi.nlm.nih.gov/pubmed/24521925


(157) Sanli T, Steinberg GR, Singh G, Tsakiridis T. AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther 2014; 15: 147-244. https://www.ncbi.nlm.nih.gov/pubmed/24100703


(156) Nashed MG, Balenko MD, Singh G. Cancer-induced oxidative stress and pain. Curr Pain Headache Rep 2014; 18: 384. 



(155) Verschoor ML, Verschoor CP, Singh G. Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers. Cancer Metab 2013; 1:17. https://www.ncbi.nlm.nih.gov/pubmed/24280356


(154) Verschoor ML, Singh G. Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer. Mol Cancer 2013; 12: 138. 



(153) Verschoor ML, Ungard R, Harbottle A, Jakupciak JP, Parr RL, Singh G. Mitochondria and cancer: past, present, and future. Biomed Research International 2013; 2013: 612369. https://www.ncbi.nlm.nih.gov/pubmed/23509753


(152) Ungard RG, Seidlitz EP, Singh G. Oxidative stress and cancer pain. Canadian Journal of Physiology and Pharmacology 2013; 91: 31-37. 



(151) Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, Tsakiridis T. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 2013; 108: 2021-2032. https://www.ncbi.nlm.nih.gov/pubmed/23632475


(150) Parr R, Harbottle A, Jakupciak JP, Singh G. Mitochondria and cancer. Biomed Res Int 2013; 2013: 763703. 



(149) Cowan RW, Singh G. Giant cell tumor of bone: a basic science perspective. Bone 2013; 52: 238-246. https://www.ncbi.nlm.nih.gov/pubmed/23063845


(148) Storozhuk Y, Sanli T, Hopmans SN, Schultz C, Farrell T, Cutz JC, Steinberg GR, Wright J, Singh G, Tsakiridis T. Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. Radiat Oncol 2012; 7: 71. https://www.ncbi.nlm.nih.gov/pubmed/22607554


(147) Sanli T, Linher-Melville K, Tsakiridis T, Singh G. Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS One 2012; 7: e32035. https://www.ncbi.nlm.nih.gov/pubmed/22363791


(146) Sanli T, Storozhuk Y, Linher-Melville K, Bristow RG, Laderout K, Viollet B, Wright J, Singh G, Tsakiridis T. Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival. Radiother Oncol2012; 102: 459-465.



(145) Linher-Melville K, Zantinge S, Singh G. Liver kinase B1 expression (LKB1) is repressed by estrogen receptor alpha (ERalpha) in MCF-7 human breast cancer cells. Biochemical and Biophysical Research Communications 2012; 417: 1063-1068. https://www.ncbi.nlm.nih.gov/pubmed/22226967


(144) Cowan RW, Seidlitz EP, Singh G. Glutamate signaling in healthy and diseased bone. Front Endocrinol (Lausanne) 2012; 3: 89. 



(143) Cowan RW, Ghert M, Singh G. T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone. Biochemical and Biophysical Research Communications 2012; 419: 719-723. https://www.ncbi.nlm.nih.gov/pubmed/22386994


(142) Cowan RW, Singh G, Ghert M. PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone. J Orthop Res 2012; 30: 877-884. 



(141) Singh S, Mak IW, Cowan RW, Turcotte R, Singh G, Ghert M. The role of TWIST as a regulator in giant cell tumor of bone. J Cell Biochem 2011; 112: 2287-2295. https://www.ncbi.nlm.nih.gov/pubmed/21503964


(140) Sanli T, Liu C, Rashid A, Hopmans SN, Tsiani E, Schultz C, Farrell T, Singh G, Wright J, Tsakiridis T. Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. J Thorac Oncol 2011; 6: 439-450. https://www.ncbi.nlm.nih.gov/pubmed/21258249


(139) Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiat Oncol 2011; 6: 144. https://www.ncbi.nlm.nih.gov/pubmed/22029423


(138) Mak IW, Cowan RW, Turcotte RE, Singh G, Ghert M. PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis. PLoS One 2011; 6: e19975. https://www.ncbi.nlm.nih.gov/pubmed/21625386


(137) Linher-Melville K, Zantinge S, Sanli T, Gerstein H, Tsakiridis T, Singh G. Establishing a relationship between prolactin and altered fatty acid beta-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. BMC Cancer 2011; 11: 56. https://www.ncbi.nlm.nih.gov/pubmed/21294903


(135) Verschoor ML, Wilson LA, Verschoor CP, Singh G. Ets-1 regulates energy metabolism in cancer cells. PLoS One 2010; 5: e13565. 



(136) Verschoor ML, Wilson LA, Singh G. Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer. Canadian Journal of Physiology

and Pharmacology 2010; 88: 204-219. https://www.ncbi.nlm.nih.gov/pubmed/20393586


(134) Singh G, Alqawi O, Espiritu M. Metronomic PDT and cell death pathways. Methods Mol Biol 2010; 635:65-78. 



(133) Sharma MK, Seidlitz EP, Singh G. Cancer cells release glutamate via the cystine/glutamate antiporter. Biochemical and Biophysical Research Communications 2010; 391: 91-95. https://www.ncbi.nlm.nih.gov/pubmed/19896463


(132) Seidlitz EP, Sharma MK, Singh G. A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processes. Canadian Journal of Physiology and Pharmacology  2010; 88: 197-203. https://www.ncbi.nlm.nih.gov/pubmed/20393585


(131) Seidlitz EP, Sharma MK, Singh G. Extracellular glutamate alters mature osteoclast and osteoblast functions. Canadian Journal of Physiology and Pharmacology 2010; 88: 929-936. https://www.ncbi.nlm.nih.gov/pubmed/20921979


(130) Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, Singh G, Wright J, Tsakiridis T. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys 2010; 78: 221-229. https://www.ncbi.nlm.nih.gov/pubmed/20615625


(129) Mak IW, Seidlitz EP, Cowan RW, Turcotte RE, Popovic S, Wu WC, Singh G, Ghert M. Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone. Hum Pathol 2010; 41: 1320-1329. https://www.ncbi.nlm.nih.gov/pubmed/20573369


(128) Lin H, Lu JP, Laflamme P, Qiao S, Shayegan B, Bryskin I, Monardo L, Wilson BC, Singh G, Pinthus JH. Inter-related in vitro effects of androgens, fatty acids and oxidative stress in prostate cancer: a mechanistic model supporting prevention strategies. Int J Oncol 2010; 37: 761-766. 



(127) De Ciantis PD, Yashpal K, Henry J, Singh G. Characterization of a rat model of metastatic prostate cancer bone pain. J Pain Res 2010; 3: 213-221.



(126) Trinkaus M, Ooi WS, Amir E, Popovic S, Kalina M, Kahn H, Singh G, Gainford MC, Clemons M. Examination of the mechanisms of osteolysis in patients with metastatic breast cancer. Oncology Reports 2009; 21: 1153-1159. https://www.ncbi.nlm.nih.gov/pubmed/19360288


(125) Sharma P, Farrell T, Patterson MS, Singh G, Wright JR, Sur R, Rainbow AJ. In vitro survival of nonsmall cell lung cancer cells following combined treatment with ionizing radiation and photofrin-mediated photodynamic therapy. Photochem Photobiol 2009; 85: 99-106. https://www.ncbi.nlm.nih.gov/pubmed/18643904


(124) Seidlitz EP, Sharma MK, Saikali Z, Ghert M, Singh G. Cancer cell lines release glutamate into the extracellular environment. Clinical & Experimental Metastasis 2009; 26: 781-787. https://www.ncbi.nlm.nih.gov/pubmed/19526315


(123) Rabinovich A, Mak IW, Cowan RW, Turcotte RE, Colterjohn N, Singh G, Ghert M. Matrix metalloproteinase activity in the stromal cell of giant cell tumor of bone. Open Bone J 2009; 1: 46-52. https://www.ncbi.nlm.nih.gov/pubmed/22287999


(122) Mak IW, Cowan RW, Popovic S, Colterjohn N, Singh G, Ghert M. Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone.Bone 2009; 45: 377-386. https://www.ncbi.nlm.nih.gov/pubmed/19422937


(121) Foroodi F, Duivenvoorden WC, Singh G. Interactions of doxycycline with chemotherapeutic agents in human breast adenocarcinoma MDA-MB-231 cells. Anticancer Drugs 2009; 20: 115-122. https://www.ncbi.nlm.nih.gov/pubmed/19209028


(120) Cowan RW, Mak IW, Colterjohn N, Singh G, Ghert M. Collagenase expression and activity in the stromal cells from giant cell tumour of bone. Bone2009; 44: 865-871. https://www.ncbi.nlm.nih.gov/pubmed/19442604


(119) Armstrong AF, Lemon JA, Czorny SK, Singh G, Valliant JF. Evaluation of single amino acid chelate derivatives and regioselective radiolabelling of a cyclic peptide for the urokinase plasminogen activator receptor. Nuclear Medicine and Biology 2009; 36: 907-917. https://www.ncbi.nlm.nih.gov/pubmed/19875047


(118) Tsakiridis T, Cutz JC, Singh G, Hirte H, Okawara G, Corbett T, Sur R, Cai W, Whelan T, Wright JR. Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy. J Thorac Oncol 2008; 3: 716-722. 



(117) Pinthus JH, Kleinmann N, Tisdale B, Chatterjee S, Lu JP, Gillis A, Hamlet T, Singh G, Farrokhyar F, Kapoor A. Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney. Eur Urol 2008; 54: 866-873. https://www.ncbi.nlm.nih.gov/pubmed/18343565


(116) Saikali Z, Setya H, Singh G, Persad S. Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells. Cancer Cell Int 2008; 8:10. 



(115) Armstrong AF, Oakley N, Parker S, Causey PW, Lemon J, Capretta A, Zimmerman C, Joyal J, Appoh F, Zubieta J, Babich JW, Singh G, Valliant JF. A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents.Chemical Communications 2008;  5532-5534. https://www.ncbi.nlm.nih.gov/pubmed/18997942


(114) Amir E, Ooi WS, Simmons C, Kahn H, Christakis M, Popovic S, Kalina M, Chesney A, Singh G, Clemons M. Discordance between receptor status in primary

and metastatic breast cancer: an exploratory study of bone and bone marrow biopsies. Clin Oncol (R Coll Radiol) 2008; 20: 763-768. 



(113) Richardson M, Liu L, Dunphy L, Wong D, Sun Y, Viswanathan K, Singh G, Lucas A. Viral serpin, Serp-1, inhibits endogenous angiogenesis in the chicken chorioallantoic membrane model. Cardiovasc Pathol 2007; 16: 191-202. https://www.ncbi.nlm.nih.gov/pubmed/17637427


(112) Pinthus JH, Lu JP, Bidaisee LA, Lin H, Bryskine I, Gupta RS, Singh G. Androgen-dependent regulation of medium and long chain fatty acids uptake in prostate cancer. Prostate 2007; 67: 1330-1338. https://www.ncbi.nlm.nih.gov/pubmed/17626249


(111) Pinthus JH, Bryskin I, Trachtenberg J, Lu JP, Singh G, Fridman E, Wilson BC. Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy. Neoplasia 2007; 9: 68-80. https://www.ncbi.nlm.nih.gov/pubmed/17325745


(110) Ghert M, Simunovic N, Cowan RW, Colterjohn N, Singh G. Properties of the stromal cell in giant cell tumor of bone. Clin Orthop Relat Res 2007; 459: 8-13.



(109) Duivenvoorden WC, Vukmirovic-Popovic S, Kalina M, Seidlitz E, Singh G. Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer. British Journal of Cancer 2007; 96: 1526-1531. https://www.ncbi.nlm.nih.gov/pubmed/17437017


(108) Chowdhury SK, Raha S, Tarnopolsky MA, Singh G. Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer. Free Radic Res 2007; 41: 1116-1124. https://www.ncbi.nlm.nih.gov/pubmed/17886033


(107) Alqawi O, Wang HP, Espiritu M, Singh G. Chronic hypoxia promotes an aggressive phenotype in rat prostate cancer cells. Free Radic Res 2007; 41: 788-797. https://www.ncbi.nlm.nih.gov/pubmed/17577739


(106) Jandu N, Richardson M, Singh G, Hirte H, Hatton MW. Human ovarian cancer ascites fluid contains a mixture of incompletely degraded soluble products of fibrin that collectively possess an antiangiogenic property. Int J Gynecol Cancer 2006; 16: 1536-1544. https://www.ncbi.nlm.nih.gov/pubmed/16884362


(105) Hatton MW, Southward SM, Ross BL, Clarke BJ, Singh G, Richardson M. Relationships among tumor burden, tumor size, and the changing concentrations of fibrin degradation products and fibrinolytic factors in the pleural effusions of rabbits with VX2 lung tumors. J Lab Clin Med 2006; 147: 27-35. https://www.ncbi.nlm.nih.gov/pubmed/16443002


(104) Alqawi O, Moghaddas M, Singh G. Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells. Prostate Cancer Prostatic Dis 2006; 9: 126-135. https://www.ncbi.nlm.nih.gov/pubmed/16432534


(102) Wilson LA, Gemin A, Espiritu R, Singh G. ets-1 is transcriptionally up-regulated by H2O2 via an antioxidant response element. FASEB J 2005; 19: 2085-2087.



(103) Zacal N, Espiritu M, Singh G, Rainbow AJ. Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells. Biochemical and Biophysical Research Communications 2005; 331: 648-657. https://www.ncbi.nlm.nih.gov/pubmed/15850808


(101) Szabo KA, Singh G. Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells. Breast Cancer Res 2005; 7: R661-R668. 



(100) Shen XY, Zacal N, Singh G, Rainbow AJ. Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. Photochem Photobiol 2005; 81: 306-313. https://www.ncbi.nlm.nih.gov/pubmed/15560738


(99) Richardson M, Wong D, Lacroix S, Stanisz J, Singh G. Inhibition by doxycycline of angiogenesis in the chicken chorioallantoic membrane (CAM).Cancer Chemother Pharmacol 2005; 56: 1-9. https://www.ncbi.nlm.nih.gov/pubmed/15726364


(98) Khalili P, Arakelian A, Chen GP, Singh G, Rabbani SA. Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer. Oncogene 2005; 24: 6657-6666. https://www.ncbi.nlm.nih.gov/pubmed/16091754


(97) Gemin A, Sweet S, Preston TJ, Singh G. Regulation of the cell cycle in response to inhibition of mitochondrial generated energy. Biochemical and Biophysical Research Communications 2005; 332: 1122-1132. https://www.ncbi.nlm.nih.gov/pubmed/15925326


(96) Dysart JS, Singh G, Patterson MS. Calculation of singlet oxygen dose from photosensitizer fluorescence and photobleaching during mTHPC photodynamic therapy of MLL cells. Photochemistry and Photobiology 2005; 81: 196-205. https://www.ncbi.nlm.nih.gov/pubmed/15469385


(95) Chowdhury SKR, Gemin A, Singh G. High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Biochemical and Biophysical Research Communications 2005; 333: 1139-1145. https://www.ncbi.nlm.nih.gov/pubmed/15967408


(94) Wilson LA, Yamamoto H, Singh G. Role of the transcription factor Ets-1 in cisplatin resistance. Mol Cancer Ther 2004; 3: 823-832. 



(93) Seidlitz E, Korbie D, Marien L, Richardson M, Singh G. Quantification of anti-angiogenesis using the capillaries of the chick chorioallantoic membrane demonstrates that the effect of human angiostatin is age-dependent. Microvascular Research 2004; 67: 105-116. 



(92) Hatton MW, Southward SM, Legault KJ, Ross BL, Clarke BJ, Bajzar L, Blajchman MA, Singh G, Richardson M. Fibrinogen catabolism within the procoagulant VX-2 tumor of rabbit lung in vivo: Effluxing fibrin(ogen) fragments contain antiangiogenic activity. J Lab Clin Med 2004; 143: 241-254. 



(91) Caney C, Singh G, Lukka H, Rainbow AJ. Combined gamma-irradiation and subsequent cisplatin treatment in human squamous carcinoma cell lines sensitive and resistant to cisplatin. Int J Radiat Biol 2004; 80: 291-299. https://www.ncbi.nlm.nih.gov/pubmed/15204706


(90) van Lieshout T, Stanisz J, Espiritu V, Richardson M, Singh G. A hypoxic response induced in MatLyLu cells by cobalt chloride results in an enhanced angiogenic response by the chick chorioallantoic membrane. International Journal of Oncology 2003; 23: 745-750. https://www.ncbi.nlm.nih.gov/pubmed/12888912


(89) Tong ZM, Singh G, Valerie K, Rainbow AJ. Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy. Journal of Photochemistry and Photobiology B-Biology 2003; 71: 77-85. https://www.ncbi.nlm.nih.gov/pubmed/14705642


(88) Singh S, Sadacharan S, Su S, Belldegrun A, Persad S, Singh G. Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Research 2003; 63: 2306-2311. https://www.ncbi.nlm.nih.gov/pubmed/12727854


(87) Saikali Z, Singh G. Doxycycline and other tetracyclines in the treatment of bone metastasis. Anticancer Drugs 2003; 14: 773-778. 



(86) Richardson M, Singh G. Observations on the use of the avian chorioallantoic membrane (CAM) model in investigations into angiogenesis. Curr Drug Targets Cardiovasc Haematol Disord 2003; 3: 155-185. https://www.ncbi.nlm.nih.gov/pubmed/12769641


(85) Preston TJ, Woodgett JR, Singh G. JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Exp Cell Res 2003; 285: 146-158. https://www.ncbi.nlm.nih.gov/pubmed/12681294


(84) Jiang F, Robin AM, Katakowski M, Tong L, Espiritu M, Singh G, Chopp M. Photodynamic therapy with photofrin in combination with Buthionine Sulfoximine (BSO) of human glioma in the nude rat. Lasers in Medical Science 2003; 18: 128-133. https://www.ncbi.nlm.nih.gov/pubmed/14505195


(83) Giles ED, Singh G. Role of insulin-like growth factor binding proteins (IGFBPs) in breast cancer proliferation and metastasis. Clinical & Experimental Metastasis 2003; 20: 481-487. https://www.ncbi.nlm.nih.gov/pubmed/14598881


(82) Wang HP, Hanlon JG, Rainbow AJ, Espiritu M, Singh G. Up-regulation of Hsp27 plays a role in the resistance of human colon carcinoma HT29 cells to photooxidative stress. Photochem Photobiol 2002; 76: 98-104. https://www.ncbi.nlm.nih.gov/pubmed/12126313


(81) Vukmirovic-Popovic S, Colterjohn N, Lhotak S, Duivenvoorden WCM, Orr FW, Singh G. Morphological, histomorphometric, and microstructural alterations in human bone metastasis from breast carcinoma. Bone 2002; 31: 529-535. https://www.ncbi.nlm.nih.gov/pubmed/12398951


(80) Tong Z, Singh G, Rainbow AJ. Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy. Cancer Res 2002; 62: 5528-5535. https://www.ncbi.nlm.nih.gov/pubmed/12359764


(79) Singh S, Barrett J, Sakata K, Tozer RG, Singh G. ETS proteins and MMPs: partners in invasion and metastasis. Curr Drug Targets 2002; 3: 359-367. 



(78) Richardson M, Gunawan J, Hatton MW, Seidlitz E, Hirte HW, Singh G. Malignant ascites fluid (MAF), including ovarian-cancer-associated MAF, contains angiostatin and other factor(s) which inhibit angiogenesis. Gynecol Oncol 2002; 86: 279-287. https://www.ncbi.nlm.nih.gov/pubmed/12217749


(77) Hatton MW, Southward SM, Ross BL, Legault K, Marien L, Korbie D, Richardson M, Singh G, Clarke BJ, Blajchman MA. Angiostatin II is the predominant glycoform in pleural effusates of rabbit VX-2 lung tumors. J Lab Clin Med 2002; 139: 316-323. https://www.ncbi.nlm.nih.gov/pubmed/12032493


(76) Dysart JS, Patterson MS, Farrell TJ, Singh G. Relationship between mTHPC fluorescence photobleaching and cell viability during in vitro photodynamic treatment of DP16 cells. Photochemistry and Photobiology 2002; 75: 289-295. https://www.ncbi.nlm.nih.gov/pubmed/11950095


(75) Duivenvoorden WC, Popovic SV, Lhotak S, Seidlitz E, Hirte HW, Tozer RG, Singh G. Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Cancer Research 2002; 62: 1588-1591. https://www.ncbi.nlm.nih.gov/pubmed/11912125


(74) Barrett JM, Puglia MA, Singh G, Tozer RG. Expression of Ets-related transcription factors and matrix metalloproteinase genes in human breast cancer cells. Breast Cancer Research and Treatment 2002; 72: 227-232. https://www.ncbi.nlm.nih.gov/pubmed/12058964


(73) Tong ZM, Singh G, Rainbow AJ. Extreme dark cytotoxicity of Nile Blue A in normal human fibroblasts. Photochemistry and Photobiology 2001; 74: 707-711.



(72) Singh G, Espiritu M, Shen XY, Hanlon JG, Rainbow AJ. In vitro induction of PDT resistance in HT29, HT1376 and SK-N-MC cells by various photosensitizers. Photochem Photobiol 2001; 73: 651-656. https://www.ncbi.nlm.nih.gov/pubmed/11421071


(71) Preston TJ, Muller WJ, Singh G. Scavenging of extracellular H2O2 by catalase inhibits the proliferation of HER-2/Neu-transformed rat-1 fibroblasts through the induction of a stress response. J Biol Chem 2001; 276: 9558-9564. https://www.ncbi.nlm.nih.gov/pubmed/11134000


(70) Preston TJ, Abadi A, Wilson L, Singh G. Mitochondrial contributions to cancer cell physiology: potential for drug development. Adv Drug Deliv Rev2001; 49: 45-61. https://www.ncbi.nlm.nih.gov/pubmed/11377802


(69) Hatton MW, Day S, Southward SM, Dereske M, Ross B, Seidlitz E, Singh G, Richardson M. Metabolism of rabbit angiostatin glycoforms I and II in rabbits:

angiostatin-I leaves the intravascular space faster and appears to have greater anti-angiogenic activity than angiostatin-II. J Lab Clin Med2001; 138: 83-93.



(68) Hanlon JG, Adams K, Rainbow AJ, Gupta RS, Singh G. Induction of Hsp60 by Photofrin-mediated photodynamic therapy. J Photochem Photobiol B2001; 64: 55-61. https://www.ncbi.nlm.nih.gov/pubmed/11705730


(67) Duivenvoorden WC, Hirte HW, Singh G. Quantification of matrix metalloproteinase activity in plasma of patients enrolled in a BAY 12-9566 phase I study. Int J Cancer 2001; 91: 857-862. https://www.ncbi.nlm.nih.gov/pubmed/11275992


(66) Weber MH, Goltzman D, Kostenuik P, Rabbani S, Singh G, Duivenvoorden WC, Orr FW. Mechanisms of tumor metastasis to bone. Crit Rev Eukaryot Gene Expr 2000; 10: 281-302. https://www.ncbi.nlm.nih.gov/pubmed/11272470


(65) Tong Z, Singh G, Rainbow AJ. The role of the p53 tumor suppressor in the response of human cells to photofrin-mediated photodynamic therapy.Photochem Photobiol 2000; 71: 201-210. https://www.ncbi.nlm.nih.gov/pubmed/10687395


(64) Porter LA, Singh G, Lee JM. Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis. Blood 2000; 95: 2645-2650. 



(63) Orr FW, Lee J, Duivenvoorden WC, Singh G. Pathophysiologic interactions in skeletal metastasis. Cancer 2000; 88: 2912-2918.



(62) Moorehead RA, Singh G. Influence of the proto-oncogene c-fos on cisplatin sensitivity. Biochem Pharmacol 2000; 59: 337-345. 



(61) Lhotak S, Elavathil LJ, Vukmirovic-Popovic S, Duivenvoorden WC, Tozer RG, Singh G. Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma. Clinical & Experimental Metastasis 2000; 18: 463-470. https://www.ncbi.nlm.nih.gov/pubmed/11592303


(60) Sweet S, Singh G. Changes in mitochondrial mass, membrane potential, and cellular adenosine triphosphate content during the cell cycle of human leukemic (HL-60) cells. J Cell Physiol 1999; 180: 91-96.


(59) Schreiber M, Muller WJ, Singh G, Graham FL. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1) in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene 1999; 18: 1663-1676.


(58) Moorehead RA, Singh G. Mitochondrial membrane potential regulation is independent of c-fos expression. Canadian Journal of Physiology and Pharmacology 1999; 77: 195-203.


(57) Duivenvoorden WCM, Hirte HW, Singh G. Transforming growth factor beta 1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. Clinical & Experimental Metastasis 1999; 17: 27-34.


(56) Caney C, Bulmer JT, Singh G, Lukka H, Rainbow AJ. Pre-exposure of human squamous carcinoma cells to low-doses of gamma-rays leads to an increased resistance to subsequent low-dose cisplatin treatment. Int J Radiat Biol 1999; 75: 963-972.


(55) Adams K, Rainbow AJ, Wilson BC, Singh G. In vivo resistance to photofrin-mediated photodynamic therapy in radiation-induced fibrosarcoma cells resistant to in vitro Photofrin-mediated photodynamic therapy. J Photochem Photobiol B 1999; 49: 136-141.


(54) Sweet S, Duivenvoorden W, Singh G. Mitochondria as a critical target for toxicity. In Vitro & Molecular Toxicology-A Journal of Basic and Applied Research 1998; 11: 73-81.


(53) Sanchez-Sweatman OH, Orr FW, Singh G. Human metastatic prostate PC3 cell lines degrade bone using matrix metalloproteinases. Invasion and Metastasis 1998; 18: 297-305.


(52) Jiang F, Lilge L, Belcuig M, Singh G, Grenier J, Li Y, Chopp M. Photodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain. Lasers Surg Med 1998; 23: 161-166.


(51) Austin RC, Sood SK, Dorward AM, Singh G, Shaughnessy SG, Pamidi S, Outinen PA, Weitz JI. Homocysteine-dependent alterations in mitochondrial gene expression, function and structure - Homocysteine and H2O2 act synergistically to enhance mitochondrial damage. Journal of Biological Chemistry 1998; 273: 30808-30817.


(50) Wilson BC, Olivo M, Singh G. Subcellular localization of Photofrin(R) and aminolevulinic acid and photodynamic cross-resistance in vitro in radiation-induced fibrosarcoma cells sensitive or resistant to photofrin-mediated photodynamic therapy. Photochemistry and Photobiology 1997; 65: 166-176.


(49) Sanchez-Sweatman OH, Lee J, Orr FW, Singh G. Direct osteolysis induced by metastatic murine melanoma cells: role of matrix metalloproteinases.European Journal of Cancer 1997; 33: 918-925.


(48) Sanchez-Sweatman O, Soares F, Whaley M, Khokha R, Orr F, Singh G. Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors. Int J Oncol 1997; 11: 1321-1326.


(47) Kostenuik PJ, Singh G, Orr FW. Transforming growth factor beta upregulates the integrin-mediated adhesion of human prostatic carcinoma cells to type I collagen. Clinical & Experimental Metastasis 1997; 15: 41-52.


(46) Duivenvoorden WC, Hirte HW, Singh G. Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Invasion and Metastasis 1997; 17: 312-322.


(45) Dorward A, Sweet S, Moorehead R, Singh G. Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance. J Bioenerg Biomembr 1997; 29: 385-392.


(44) DiProspero L, Singh G, Wilson BC, Rainbow AJ. Cross-resistance to photofrin-mediated photodynamic therapy and UV light and recovery from photodynamic therapy damage in Rif-8A mouse fibrosarcoma cells measured using viral capacity. J Photochem Photobiol B 1997; 38: 143-151.


(43) Sanchez-Sweatman O, Orr FW, Singh G. Comparative in vivo and in vitro proliferation of murine tumor cells in the bone microenvironment.International Journal of Oncology 1996; 8: 371-376.


(42) Moorehead RA, Armstrong SG, Rainbow AJ, Singh G. Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*). Cancer Chemother Pharmacol 1996; 38: 245-253.


(41) Kostenuik PJ, Sanchez-Sweatman O, Orr FW, Singh G. Bone cell matrix promotes the adhesion of human prostatic carcinoma cells via the alpha 2 beta 1 integrin. Clinical & Experimental Metastasis 1996; 14: 19-26.


(40) Dorward AM, Singh G. Energetic characteristics of cisplatin resistant ovarian carcinoma cells. Anticancer Res 1996; 16: 443-447.


(39) Sweet S, Singh G. Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints. Cancer Res 1995; 55: 5164-5167.


(38) Singh G, Dorward A, Moorehead R, Sweet S. Novel mechanisms of resistance to cancer chemotherapy. Cancer Journal - France 1995; 8: 304-307.


(37) Sagar SM, Singh G, Hodson DI, Whitton AC. Nitric oxide and anti-cancer therapy. Cancer Treat Rev 1995; 21: 159-181.


(36) Orr FW, Sanchez-Sweatman OH, Kostenuik P, Singh G. Tumor-bone interactions in skeletal metastasis. Clin Orthop Relat Res 1995;  19-33.


(35) Moorehead R, Singh G. Sensitisation of cisplatin-resistant cells using dequalinium chloride. Cellular Pharmacology 1995; 2: 311-317.


(34) Moorehead RA, Armstrong SG, Wilson BC, Singh G. Cross-resistance to cisplatin in cells resistant to photofrin-mediated photodynamic therapy.Cancer Res 1994; 54: 2556-2559.


(33) Armstrong SG, Browman GP, Benger AM, Meyer RM, McKay KL, Singh G. Relation between platinum-DNA adducts and complete remission in adult acute nonlymphocytic leukemia. Leuk Res 1994; 18: 659-664.


(32) Sharkey SM, Wilson BC, Moorehead R, Singh G. Mitochondrial alterations in photodynamic therapy-resistant cells. Cancer Res 1993; 53: 4994-4999.


(31) Orr FW, Kostenuik P, Sanchez-Sweatman OH, Singh G. Mechanisms involved in the metastasis of cancer to bone. Breast Cancer Research and Treatment 1993; 25: 151-163.


(30) Kostenuik PJ, Orr FW, Suyama K, Singh G. Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats. Cancer Res 1993; 53: 5452-5457.


(29) Kostenuik P, Orr F, Arsenault L, Millar-Book W, Singh G. Increased expression of C-myc messenger-RNA and protein in Walker 256 cancer-cells stimulated by bone-derived conditioned media and by transforming-growth-factor-Beta (TGF-beta). Int J Oncol 1993; 3: 729-734.


(28) Singh G, Sharkey SM, Moorehead R. Mitochondrial DNA damage by anticancer agents. Pharmacol Ther 1992; 54: 217-230.


(27) Singh G. Relationship between mtDNA and mitochondrial function. Recent Advances in Cellular and Molecular Biology, Vol 2: Progress in Genes and Genetics 1992; 2: 117-122.


(26) Singh G, Moorehead R. Mitochondria as a target for combination cancer-chemotherapy. Int J Oncol 1992; 1: 825-829.


(25) Kostenuik PJ, Singh G, Suyama KL, Orr FW. A quantitative model for spontaneous bone metastasis - evidence for a mitogenic effect of bone on Walker-256 cancer cells. Clinical & Experimental Metastasis 1992; 10: 403-410.


(24) Kostenuik PJ, Singh G, Suyama KL, Orr FW. Stimulation of bone-resorption results in a selective increase in the growth-rate of spontaneously metastatic Walker-256 cancer cells in bone. Clinical & Experimental Metastasis 1992; 10: 411-418.


(23) Singh G, Veltri KL. Effects of differentiation of embryonal carcinoma cells (P19) on mitochondrial DNA content in vitro. In Vitro Cell Dev Biol 1991; 27A: 557-561.


(22) Singh G, Veltri KL. A mechanism for the loss of cytochrome P-450 in primary mouse hepatocytes. Mol Cell Biochem 1991; 108: 151-156.


(21) Singh G, Wilson BC, Sharkey SM, Browman GP, Deschamps P. Resistance to photodynamic therapy in radiation induced fibrosarcoma-1 and Chinese hamster ovary-multi-drug resistant cells in vitro. Photochem Photobiol 1991; 54: 307-312.


(20) Singh G. Mitochondrial DNA mtDNA as a critical target for cisplatin-induced nephrotoxicity. Anti-Cancer Drug Design 1991; 6: 275-276.


(19) Veltri KL, Espiritu M, Singh G. Distinct genomic copy number in mitochondria of different mammalian organs. J Cell Physiol 1990; 143: 160-164.


(18) Singh G, Veltri K, Maniccia-Bozzo E. Relationship between drug-induced organ specific toxicity and mitochondrial genomic regulation and content.European Journal of Pharmacology 1990; 183: 1105-1106.


(17) Singh G, Maniccia-Bozzo E. Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatment. Cancer Chemother Pharmacol 1990; 26: 97-100.


(16) Orr FW, Millar-Book W, Singh G. Chemotactic activity of bone and platelet-derived TGF-beta for bone-metastasizing rat Walker 256 carcinosarcoma cells. Invasion and Metastasis 1990; 10: 241-252.


(15) Neville AJ, Singh G. Effect of whole-body hyperthermia on hepatic cytochrome P450. Cancer Chemother Pharmacol 1990; 25: 342-344.


(14) Millar-Book W, Orr FW, Singh G. In vitro effects of bone- and platelet-derived transforming growth factor-beta on the growth of Walker 256 carcinosarcoma cells. Clinical & Experimental Metastasis 1990; 8: 503-510.


(13) Maniccia-Bozzo E, Espiritu MB, Singh G. Differential effects of cisplatin on mouse hepatic and renal mitochondrial DNA. Mol Cell Biochem 1990; 94: 83-88.


(12) Singh G. A possible cellular mechanism of cisplatin-induced nephrotoxicity. Toxicology 1989; 58: 71-80.


(11) Singh G, Koropatnick J. Differential toxicity of cis and trans isomers of dichlorodiammineplatinum. J Biochem Toxicol 1988; 3: 223-233.


(10) Singh G, Shaughnessy SG. Functional impairment induced by lipophilic cationic compounds on mitochondria. Canadian Journal of Physiology and Pharmacology 1988; 66: 243-245.


(9) Singh G, Jeeves WP, Wilson BC, Jang D. Mitochondrial photosensitization by Photofrin-Ii. Photochemistry and Photobiology 1987; 46: 645-649.


(8) Singh G, Hauswirth WW, Ross WE, Neims AH. A method for assessing damage to mitochondrial DNA caused by radiation and epichlorohydrin. Mol Pharmacol 1985; 27: 167-170.


(7) Singh G, Renton KW. Inhibition of the synthesis of hepatic cytochrome P-450 by the interferon-inducing agent poly rI.rCi. Can J Physiol Pharmacol1984; 62: 379-383.


(6) Renton KW, Singh G, Stebbing N. Relationship between the antiviral effects of interferons and their abilities to depress cytochrome P-450. Biochem Pharmacol 1984; 33: 3899-3902.


(5) Neims AH, Hawke RL, Raynor L, Singh G. Regulation of microsomal testosterone 15 alpha-hydroxylase activity in inbred mouse liver and kidney.Biochem Soc Trans 1984; 12: 45-48.


(4) Singh G, Renton KW, Stebbing N. Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation. Biochemical and

Biophysical Research Communications 1982; 106: 1256-1261.


(3) Singh G, Renton KW. Interferon-mediated depression of cytochrome P-450-dependent drug biotransformation. Mol Pharmacol 1981; 20: 681-684.


(2) Macdonald IA, Singh G, Markus IS, Tan MH. Suppression of human fecal 7 alpha-hydroxysteroid dehydrogenase by a short-term low cholesterol diet.J Steroid Biochem 1980; 13: 323-332.


(1) Macdonald IA, Singh G, Mahony DE, Meier CE. Effect of pH on bile salt degradation by mixed fecal cultures. Steroids 1978; 32: 245-256.